A patient develops hives during an IV penicillin infusion. Which action is appropriate?

• A. Reassess the patient in 15 minutes
• B. Discontinue IV and continue normal saline then report to Dr.
• C. Call the patient’s family
• D. Apply a cold compress

Answer: (B)

Hives during IV penicillin indicate an immediate allergic reaction to the drug. The priority is to stop exposing the patient to the allergen right away. Discontinue the penicillin infusion and keep the IV line open with normal saline to maintain circulation and access, then notify the physician so appropriate treatment can be started (such as antihistamines or other ordered interventions). Reassessing in 15 minutes would delay potentially life-saving care. Calling the family or applying a cold compress doesn’t address the reaction itself.